| Identification | Back Directory | [Name]
1H-Thiopyrano[4,3-b][1]benzothiophene-3-carboxamide, 6,7,8,9-tetrahydro-N-[3-(3-methyl-1-piperidinyl)propyl]- | [CAS]
931963-55-2 | [Synonyms]
E722-2648
1H-Thiopyrano[4,3-b][1]benzothiophene-3-carboxamide, 6,7,8,9-tetrahydro-N-[3-(3-methyl-1-piperidinyl)propyl]- | [Molecular Formula]
C21H30N2OS2 | [MOL File]
931963-55-2.mol | [Molecular Weight]
390.61 |
| Hazard Information | Back Directory | [Uses]
E722-2648 is a potent β-catenin/BCL9 complex inhibitor. E722-2648 specifically inhibits β-catenin/BCL9 complex formation and Wnt activity. E722-2648 disrupts cholesterol homeostasis via increased cholesterol esterification and lipid droplet accumulation. E722-2648 has antitumor activity[1]. | [References]
[1] Tanton H, et al. A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. Sci Adv. 2022 Apr 29;8(17):eabm3108. DOI:10.1126/sciadv.abm3108 |
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| Company Name: |
DC Chemicals
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021-8447131 13564518121 |
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https://www.chemicalbook.com/ShowSupplierProductsList927327/0_EN.htm |
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