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L-651392 is an orally active and specific 5-lipoxygenase inhibitor that inhibits the production of leukotrienes. L-651392 controls the inflammatory process in Escherichia coli pyelonephritis by preventing inflammatory cells from reaching the site of infection and protecting the renal tubules from inflammation-related damage during pyelonephritis[1]. | [References]
[1] Tardif M, et al. L-651,392, a potent leukotriene inhibitor, controls inflammatory process in Escherichia coli pyelonephritis[J]. Antimicrobial agents and chemotherapy, 1994, 38(7): 1555-1560. DOI:10.1128/AAC.38.7.1555 |
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