ChemicalBook--->CAS DataBase List--->93468-89-4

93468-89-4

93468-89-4 Structure

93468-89-4 Structure
IdentificationBack Directory
[Name]

(+/-)-BAY K 8644
[CAS]

93468-89-4
[Synonyms]

(+/-)-BAY K 8644
BAY K-8644 (+/-)
(±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem
(+)-(S)-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylic acid
1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-[TRIFLUOROMETHYL]PHENYL)PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2'-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[2-(TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID, METHYL ESTER
[Molecular Formula]

C16H15F3N2O4
[MDL Number]

MFCD00036697
[MOL File]

93468-89-4.mol
[Molecular Weight]

356.3
Chemical PropertiesBack Directory
[Melting point ]

166-172 °C
[storage temp. ]

2-8°C
[solubility ]

DMSO: 184 mg/mL
[form ]

Yellow solid
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/38
[Safety Statements ]

26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Definition]

ChEBI: Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate is a pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6. It is a dihydropyridine, a methyl ester, a C-nitro compound and a member of (trifluoromethyl)benzenes.
[General Description]

Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
[Biochem/physiol Actions]

Primary TargetL-type Ca2+ channel
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