| Identification | Back Directory | [Name]
NRC-2694 | [CAS]
936446-61-6 | [Synonyms]
NRC-2694
4-(3-ethynylanilino)-6-(3-morpholinopropoxy)-7-methoxyquinazoline
4-Quinazolinamine, N-(3-ethynylphenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-
inhibit,NRC-2694,HER1,EGFR,Epidermal growth factor receptor,ErbB-1,NRC 2694,Inhibitor,NRC2694 | [Molecular Formula]
C24H26N4O3 | [MOL File]
936446-61-6.mol | [Molecular Weight]
418.49 |
| Chemical Properties | Back Directory | [Boiling point ]
597.6±50.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (597.39 mM) | [form ]
Solid | [pka]
7.00±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. NRC-2694 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
In toxicity studies, the maximum tolerated dose of NRC-2694 in male and female mice is 2000 mg/kg (po). NRC-2694 (10 mg/kg) regresses the tumor in mice[1]. | [IC 50]
EGFR | [storage]
Store at -20°C | [References]
[1] Ramanadham Jyothi Prasad, et al. 6-7,dialkoxy quinazoline derivatives useful for treatment of cancer related disorders. US 8143250 B2 |
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| Company Name: |
Twochem Co.Ltd.
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| Telephone: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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