| Identification | Back Directory | [Name]
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole | [CAS]
937807-66-4 | [Synonyms]
Neurodazine
2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole
1H-Imidazole, 2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-
2-[5-(3-Chloro-phenyl)-furan-2-yl]-4,5-bis-(4-methoxy-phenyl)-1H-imidazole | [Molecular Formula]
C27H21ClN2O3 | [MDL Number]
MFCD08906055 | [MOL File]
937807-66-4.mol | [Molecular Weight]
456.92 |
| Chemical Properties | Back Directory | [Boiling point ]
661.4±55.0 °C(Predicted) | [density ]
1.252±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: >20mg/mL | [form ]
powder, yellow | [pka]
12.84±0.10(Predicted) | [color ]
Beige | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | [InChI]
1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30) | [InChIKey]
FEEOFPAEDSMOTO-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1)-c2nc([nH]c2-c3ccc(OC)cc3)-c4ccc(o4)-c5cccc(Cl)c5 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25-41 | [Safety Statements ]
26-39-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
1 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Chronic 4
Eye Dam. 1 |
| Hazard Information | Back Directory | [Description]
Neurodazine (937807-66-4) was able to induce neurogenesis of non-pluripotent myoblasts and cells derived from mature, human skeletal muscle (using 2 μM neurodazine). It was able to upregulate genes involved in neurogenesis (particularly B-cell translocation gene 2) without affecting those involved in myogenesis. | [Uses]
Neurodazine induces neurogenesis in mature skeletal muscle cells, via non-pluripotent C2C12 myoblasts. | [Definition]
ChEBI: 2-[5-(3-chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole is a member of imidazoles. | [General Description]
A cell-permeable trisubstituted imidazole compound that induces neurogenesis of non-pluripotent C2C12 myoblasts as well as cells derived from mature human skeletal muscle cultures (2 μM for 7-10 days). Shown to preferentially upregulate genes involved in neurogenesis, but not those pertaining to myogenesis, in C2C12 myoblasts. | [Biochem/physiol Actions]
Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells. | [storage]
Store at -20°C | [References]
1) Williams?et al. (2007),?Synthetic small molecules that induce neurogenesis in skeletal muscle; J. Am. Chem. Soc.,?129?9258 |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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