| Identification | Back Directory | [Name]
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- | [CAS]
937820-89-8 | [Synonyms]
JC2-11
(2E)-1-(3-Fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- | [Molecular Formula]
C17H15FO4 | [MOL File]
937820-89-8.mol | [Molecular Weight]
302.3 |
| Chemical Properties | Back Directory | [Boiling point ]
482.0±45.0 °C(Predicted) | [density ]
1.257±0.06 g/cm3(Predicted) | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
9.67±0.31(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1]. | [in vivo]
JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibits the release of caspase-1 (p20) and IL-1β in non-canonical (NC) inflammatory bodies, and weakens the activation of NC inflammatory bodies of C57BL/6 mice model[1]. | Animal Model: | C57BL/6 mice (8 weeks, female)[1]. | | Dosage: | 250 μg/mouse. | | Administration: | Intraperitoneal injection; single dose. | | Result: | Exhibited inhibitory effect on NC inflammatory body. |
| [IC 50]
NLRP3 inflammasome | [References]
[1] Lee G, et al, JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022 Dec 28;12(1):22484. DOI:10.1038/s41598-022-27129-3 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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