| Identification | Back Directory | [Name]
FIPI | [CAS]
939055-18-2 | [Synonyms]
FIPI
CS-1511
FIPI HYDROCHLORIDE
5-Fluoro-2-Indolyl des-Chlorohalopemide
5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide
N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide
N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride | [Molecular Formula]
C23H24FN5O2 | [MDL Number]
MFCD18382115 | [MOL File]
939055-18-2.mol | [Molecular Weight]
421.47 |
| Chemical Properties | Back Directory | [density ]
1.349±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 14.67 mg/mL (34.81 mM; Need ultrasonic and warming) | [form ]
Powder | [pka]
12.04±0.30(Predicted) | [color ]
Light yellow to khaki | [SMILES]
O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3 |
| Hazard Information | Back Directory | [Uses]
FIPI is a a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis. | [Definition]
ChEBI: FIPI is a member of benzimidazoles. | [in vivo]
FIPI (3 mg/kg; intraperitoneal injection; 2 times) shows protective effect in carotid thrombosis model and ischemic stroke model[4]. | Animal Model: | Ferric chloride (HY-Y0266) or transient middle cerebral artery occlusion treated mice[4] | | Dosage: | 3 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 2 times, 12 h apart | | Result: | Delayed the thrombus formation and only 3 of 9 vessels occluded during the 30-minute observation period in arterial thrombosis models.
Reduced the infarct volumes, improved motor and overall nerve function and did not impair normal hemostasis in ischemic stroke models. |
| [IC 50]
PLD1; PLD2 |
|
| Company Name: |
Acesys Pharmatech
|
| Tel: |
18860950986 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15849/0_EN.htm |
|