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939055-18-2

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939055-18-2 Structure

939055-18-2 Structure
IdentificationBack Directory
[Name]

FIPI
[CAS]

939055-18-2
[Synonyms]

FIPI
CS-1511
FIPI HYDROCHLORIDE
5-Fluoro-2-Indolyl des-Chlorohalopemide
5-fluoro-N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-1H-indole-2-carboxamide
N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide
N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride
[Molecular Formula]

C23H24FN5O2
[MDL Number]

MFCD18382115
[MOL File]

939055-18-2.mol
[Molecular Weight]

421.47
Chemical PropertiesBack Directory
[density ]

1.349±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 14.67 mg/mL (34.81 mM; Need ultrasonic and warming)
[form ]

Powder
[pka]

12.04±0.30(Predicted)
[color ]

Light yellow to khaki
[SMILES]

O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3
Safety DataBack Directory
[WGK Germany ]

WGK 2
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

FIPI is a a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis.
[Definition]

ChEBI: FIPI is a member of benzimidazoles.
[in vivo]

FIPI (3 mg/kg; intraperitoneal injection; 2 times) shows protective effect in carotid thrombosis model and ischemic stroke model[4].

Animal Model:Ferric chloride (HY-Y0266) or transient middle cerebral artery occlusion treated mice[4]
Dosage:3 mg/kg
Administration:Intraperitoneal injection (i.p.); 2 times, 12 h apart
Result:Delayed the thrombus formation and only 3 of 9 vessels occluded during the 30-minute observation period in arterial thrombosis models.
Reduced the infarct volumes, improved motor and overall nerve function and did not impair normal hemostasis in ischemic stroke models.
[IC 50]

PLD1; PLD2
Spectrum DetailBack Directory
[Spectrum Detail]

FIPI(939055-18-2)1HNMR
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