| Identification | Back Directory | [Name]
Bromoacetamido-PEG4-azido | [CAS]
940005-81-2 | [Synonyms]
BrCH2CONH-PEG3-N3
Bromo-amido-peg3-azide
Bromoacetamido-PEG3-N3
Bromoacetamido-PEG4-azido
Bromoacetamido-PEG4-azide
Bromoacetamido-PEG3-Azide
Bromoacetamide-PEG3-azide
Bromoacetamido-dPEG??-azide
N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]-2-bromoacetamide | [Molecular Formula]
C10H19BrN4O4 | [MDL Number]
MFCD22683302 | [MOL File]
940005-81-2.mol | [Molecular Weight]
339.19 |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG3-azide is a crosslinking reagentwith 3 PEG units. The azide group enables Click Chemistry. Bromoacetamido is a very reactive group for nucleophilic substitution. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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