| Identification | Back Directory | [Name]
Bromoacetamido-PEG3-Acid | [CAS]
1807534-79-7 | [Synonyms]
BrCH2CONH-PEG3-acid
Bromoacetamido-PEG3-Acid
Bromoacetamido-PEG3-C2-acid
Bromoacetamido-PEG3-CH2CH2COOH
Propanoic acid, 3-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C11H20BrNO6 | [MDL Number]
MFCD28950780 | [MOL File]
1807534-79-7.mol | [Molecular Weight]
342.18 |
| Hazard Information | Back Directory | [Description]
Bromoacetamido-PEG3-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bromoacetamido-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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