| Identification | More | [Name]
2-Fluoro-6-trifluoromethylpyridine | [CAS]
94239-04-0 | [Synonyms]
2-FLUORO-6-(TRIFLUOROMETHYL)PYRIDINE
2-FLUORO-6-RIFLUOROMETHYLPYRIDINE
2-Trifluoromethyl-6-fluoropyridine | [EINECS(EC#)]
428-100-3 | [Molecular Formula]
C6H3F4N | [MDL Number]
MFCD03092901 | [Molecular Weight]
165.09 | [MOL File]
94239-04-0.mol |
| Questions And Answer | Back Directory | [Synthesis]
At 0°C, 2-chloro-6-trichloromethylpyridine, hydrofluoric acid, ferric chloride, and solvent were slowly added to a vacuum-dried pressure-resistant tube. The resulting mixture was stirred at 170°C for 4 hours, and the reaction progress was monitored by gas chromatography. The reaction was cooled to room temperature, and after the reaction was complete, a saturated sodium carbonate aqueous solution was slowly added to the reaction system to neutralize the acid produced during the reaction, adjusting the pH of the reaction system to alkaline. After extraction with ethyl acetate, the organic layer was dried, and then evaporated to dryness to obtain the target product. 
Figure: Synthetic route of 2-fluoro-6-trifluoromethylpyridine |
| Chemical Properties | Back Directory | [Appearance]
Cloroless to light yellow liquid | [Boiling point ]
121.6±35.0 °C(Predicted) | [density ]
1.371±0.06 g/cm3(Predicted) | [vapor pressure ]
5.6hPa at 25℃ | [refractive index ]
1.4010-1.4050 | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
clear liquid | [pka]
-5.11±0.12(Predicted) | [color ]
Colorless to Almost colorless | [Water Solubility ]
1.9g/L at 25℃ | [InChI]
InChI=1S/C6H3F4N/c7-5-3-1-2-4(11-5)6(8,9)10/h1-3H | [InChIKey]
IZOIOCQPMHHDHN-UHFFFAOYSA-N | [SMILES]
C1(F)=NC(C(F)(F)F)=CC=C1 | [LogP]
1.83 at 25℃ | [CAS DataBase Reference]
94239-04-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Cloroless to light yellow liquid | [Uses]
2-Fluoro-6-trifluoromethylpyridine is a useful research chemical used in the preparation of 2-(3-alkoxy-1H-pyrazol-1-yl)azines as inhibitors of human dihydroorotate dehydrogenase. |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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