ChemicalBook--->CAS DataBase List--->943332-08-9

943332-08-9

943332-08-9 Structure

943332-08-9 Structure
IdentificationBack Directory
[Name]

AZD-6244
[CAS]

943332-08-9
[Synonyms]

Selumetinib Sulfate
[Molecular Formula]

C17H17BrClFN4O7S
[MDL Number]

MFCD28502236
[MOL File]

943332-08-9.mol
[Molecular Weight]

555.76
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 50 mg/mL (89.97 mM); Water: < 0.1 mg/mL (insoluble)
[form ]

Solid
[color ]

Light yellow to yellow
[CAS DataBase Reference]

943332-08-9
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS08,GHS09,GHS05
[Signal word ]

Danger
[Hazard statements ]

H411-H317-H361-H318-H373
[Precautionary statements ]

P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P201-P202-P281-P308+P313-P405-P501-P280-P305+P351+P338-P310-P260-P314-P501
Hazard InformationBack Directory
[Uses]

Selumetinib Sulfate (Koselugo) is a selective ATP-noncompetitive MEK1/2 inhibitor developed by Array BioPharma for the treatment of neurofibromatosis type 1 (NF1).
[Trade name]

Koselugo
[Mechanism of action]

As a MEK1/2 inhibitor, Selumetinib Sulfate inhibits the activity of mitogen-activated protein kinase (MEK), thereby affecting the RAS/RAF/MEK/ERK signaling pathway, which plays a key role in the occurrence and development of NF1-related tumors.
[Synthesis]

The synthesis started from 2,3,4-trifluorobenzoic acid (345). Nitration of 345 gave compound 346. SNAr amination of 346 gave compound 348. Esterification of 348 gave the carboxylic acid derivative 347. Final SNAr amination of 347. Reduction of the nitro group in 349 with Pd(OH)2 and in situ condensation with formic acid gave 1H-benzimidazole 350 in good yield. Sequential halogenation of 350 with NBS and NCS gave the 4-bromo-2-chloroaniline group 352. Methylation of the 1H-benzimidazole gave 353 in moderate yield. Saponification (hydrolysis) of the ester group in 353 gave compound 356. 356 was reacted with hydroxylamine 355 using an EDCI/HOBt-mediated amidation reaction to give amide 356. Acid hydrolysis of the vinyl ether in 356 gave the alcohol 357 quantitatively. Finally, selumetinib sulfate was obtained by salt formation with sulfuric acid H2SO4 in 2-butanone.
Selumetinib Sulfate synthesis
[storage]

Store at -20°C
943332-08-9 suppliers list
Company Name: Hebei Ganmiao New material Technology Co., LTD
Tel: +86-17332992504 +86-17332992504 , +86-17332992504
Website: www.hbganmiao.com/
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Beijing Mesochem Technology Co.,Ltd
Tel: +8613651027935 , +8613651027935
Website: https://www.chemicalbook.com/manufacturer/beijing-mesochem-technology-10628/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Aceschem Inc.
Tel: +1-817863-6948 +1-(817)863-6948 , +1-(817)863-6948
Website: www.aceschem.com/
Company Name: Nanjing Fred Technology Co., Ltd
Tel: +86-25-84696168 +86-15380713688 , +86-15380713688
Website: www.fredbio.com
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +86-512-68323658 +86-18168183658 , +86-18168183658
Website:
Company Name: Wuhan Circle Star Chem-medical Technology Co.,Ltd
Tel: 027-85558552 +undefined13437180835 , +undefined13437180835
Website: www.circlestar-chem.com/
Company Name: Shanghai Hanhong Scientific Co., Ltd.
Tel: +undefined17612118332 , +undefined17612118332
Website: ?www.hanhonggroup.com
Company Name: Dr. Reddy's Laboratories Ltd  
Tel: +91-4049002900 +91-4049002900
Website: www.drreddys.com
Company Name: Wuhan Linglingjiu Biotechnology Co., Ltd  Gold
Tel: 15623309010
Website: https://www.009bio.com
Company Name: wuhan dingxingtong Chemical Technology Co., Ltd Co., Ltd  Gold
Tel: 027-59207796 13429867250
Website: http://www.dxtyaoye.com
Company Name: Shanghai Kuanghao Chemistry Technology Co., Ltd.  Gold
Tel: 1590082856 15900820856
Website: www.chemicalbook.com/ShowSupplierProductsList13852/0_EN.htm
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Website: www.caerulumpharma.com
Company Name: Yangzhou QinYuan Pharmaceutical Co., Ltd.  
Tel: 0514-80939770 13773367191
Website: www.yzqyyykj.com/
Company Name: Biyu Biotechnology (Shanghai) Co., ltd  
Tel: 021-26018599
Website: www.chemicalbook.com/ShowSupplierProductsList17160/0_EN.htm
Company Name: Pharmacodia (Beijing) Co.,Ltd  
Tel: +86-400-851-9921
Website: www.pharmacodia.com
Tags:943332-08-9 Related Product Information
1313725-88-0 210644-62-5 905854-02-6 1334298-90-6 1365267-27-1 1206161-97-8 944842-54-0 790299-79-5 111358-88-4 870281-82-6 1029044-16-3 1374640-70-6 1056634-68-4 845272-21-1 405169-16-6 606143-52-6 391212-29-6

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.