| Identification | Back Directory | [Name]
SU 6668 | [CAS]
210644-62-5 | [Synonyms]
SU 6668
(Z)-SU6668
(Z)-TSU-68
(Z)-Orantinib
PDGFR Tyrosine Kinase Inhibitor VI, SU6668
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem
3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid
3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid
1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
(Z)?-?3-?(2,?4-?Dimethyl-?5-?((2-?oxoindolin-?3-?ylidene)?methyl)?-?1H-?pyrrol-?3-?yl)?propanoic acid (SU-6668) | [Molecular Formula]
C18H18N2O3 | [MDL Number]
MFCD09743433 | [MOL File]
210644-62-5.mol | [Molecular Weight]
310.35 |
| Hazard Information | Back Directory | [Uses]
PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases. | [General Description]
A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 μM, respectively). |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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SPIRO PHARMA
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www.spiropharma.com.cn |
| Company Name: |
Henan Alfachem Co.,Ltd.
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0371-0371-55051623 18137891487 |
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www.chemicalbook.com/supplier/14555231/ |
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