| Identification | Back Directory | [Name]
5-BroMo-4-fluoropyridin-2-aMine | [CAS]
944401-69-8 | [Synonyms]
152966
5-BroMo-4-fluoropyridin-2-aMine
5-Bromo-4-fluoro-2-pyridinamine
5-bromo-2-amino-4-fluoropyridine
2-aMino-5-broMo-4-fluoropyridine
5-bromo-4-fluoropyridine-2-amine
2-Pyridinamine, 5-bromo-4-fluoro-
5-Bromo-4-fluoro-pyridin-2-ylamine | [Molecular Formula]
C5H4BrFN2 | [MDL Number]
MFCD16658678 | [MOL File]
944401-69-8.mol | [Molecular Weight]
191 |
| Chemical Properties | Back Directory | [Boiling point ]
233.6±35.0 °C(Predicted) | [density ]
1.813±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
4.31±0.24(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C5H4BrFN2/c6-3-2-9-5(8)1-4(3)7/h1-2H,(H2,8,9) | [InChIKey]
GGHBRLQYBZMEPV-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(Br)C(F)=C1 |
| Hazard Information | Back Directory | [Uses]
5-BroMo-4-fluoropyridin-2-amine is a pyridine organic compound used in pharmaceutical synthesis and experiments.
| [Synthesis]
A solution of 2-amino-4-fluoropyridine (75.0 g, 0.67 mol) in anhydrous acetonitrile (700 mL) was cooled in an ice-water bath under stirring conditions. Subsequently, N-bromosuccinimide (122.8 g, 0.69 mol) was added in batches. The reaction mixture was stirred continuously for 1 hour at room temperature. After completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was washed thoroughly with water (3 x 300 mL) and then dissolved with acetonitrile and again subjected to vacuum evaporation to finally obtain 5-bromo-2-amino-4-fluoropyridine as an off-white solid (124 g, 97% yield). | [References]
[1] Patent: WO2015/86527, 2015, A1. Location in patent: Page/Page column 108
[2] Patent: WO2015/86526, 2015, A1. Location in patent: Page/Page column 110
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 719 - 724
[4] Patent: WO2018/68283, 2018, A1. Location in patent: Paragraph 00252
[5] Patent: WO2018/68282, 2018, A1. Location in patent: Paragraph 00241 |
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