| Identification | Back Directory | [Name]
Biotin-PEG3-N3 | [CAS]
945633-30-7 | [Synonyms]
Biotin-PEG3-N3
Biotin-PEG2-N3
Biotin-NH-PEG2-N3
Biotin-PEG3-azide
Reaxys ID: 18922506
(+)-Biotin-PEG?-azide
(+)-BIOTIN-PEG3-AZIDE
(+)-BIOTIN-PEG2-AZIDE
(+)-Biotin-PEG2-CH2CH2N3
(+)-Biotin-PEG2-CH2CH2N3
(+)-Biotin-PEG2-CH2CH2azide
(+)-Biotin-PEG3- CH2CH2azide
(+)-Biotin-PEG3-azide
(+)-Biotin-PEG2-azide
(+)-Biotin-PEG2-azide
Biotin-PEG3-azide *CAS 945633-30-7*
(3aS,4S,6aR)-N-[2-[2-(2-Azidoethoxy)ethoxy]ethyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
1H-Thieno[3,4-d]imidazole-4-pentanamide,N-[2-[2-(2-azidoethoxy)ethoxy]ethyl]hexahydro-2-oxo-,(3aS,4S,6aR)-
N-(2-(2-(2-Azidoethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | [Molecular Formula]
C16H28N6O4S | [MDL Number]
MFCD26142991 | [MOL File]
945633-30-7.mol | [Molecular Weight]
400.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Storage temp. 2-8°C | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Solid | [color ]
White to off-white | [Appearance]
colorless solid |
| Hazard Information | Back Directory | [Description]
Biotin-PEG2-azide is a click chemistry biotinylation reagent. The azide group enable Click Chemistry reaction with alkyne, DBCO, BCN or prppargyl moiety to form a stable triazole linkage. | [Uses]
Biotin-PEG2-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Biotin-PEG2-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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