| Identification | Back Directory | [Name]
dynorphin (1-11), Pro(10)- | [CAS]
94596-26-6 | [Synonyms]
dynorphin(1-11)
dynorphin (1-11), Pro(10)-
α-Neoendorphin (swine), 7-L-arginine-8-L-isoleucine-8a-endo-L-arginine-9-D-proline- (9CI) | [Molecular Formula]
C63H103N21O13 | [MOL File]
94596-26-6.mol | [Molecular Weight]
1362.65 |
| Hazard Information | Back Directory | [Uses]
[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property[1][2]. | [in vivo]
[DPro10] Dynorphin A (1-11), porcine (ICV) has analgesic effects involving thermal cutaneous (tail-flick) and chemical visceral (AcOH-induced writhing) stimuli, in which mu and kappa receptors are known to be activated differentially[2]. | [References]
[1] Soderstrom K, et, al. N-alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat kappa-opioid receptor. Eur J Pharmacol. 1997 Nov 5;338(2):191-7. DOI:10.1016/s0014-2999(97)81948-6
[2] Gairin JE, et, al. [D-Pro10]-dynorphin(1-11) is a kappa-selective opioid analgesic in mice. J Pharmacol Exp Ther. 1988 Jun;245(3):995-1001. PMID:2898527 |
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