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94666-15-6

94666-15-6 Structure

94666-15-6 Structure
IdentificationBack Directory
[Name]

(-)-Amosulalol
[CAS]

94666-15-6
[Synonyms]

(-)-Amosulalol
Amosulalol, (),Amosulalol, ( )
5-[(1R)-1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide
Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, (R)-
[Molecular Formula]

C18H24N2O5S
[MOL File]

94666-15-6.mol
Hazard InformationBack Directory
[Uses]

(-)-Amosulalol ((-)-YM 09538) is an isomer of Amosulalol (HY-106720), an orally active dual inhibitor of α1/β1-adrenergic receptors. Amosulalol exhibits antihypertensive activity by inhibiting α1-adrenergic receptors. Amosulalol reduces the reflex increase in heart rate and plasma renin activity (PRA) in spontaneously hypertensive rats (SHR) by inhibiting β1-adrenergic receptors.
[References]

[1] Pharmacokinetics and metabolism of an alpha,beta-blocker, amosulalol hydrochloride, in mice: biliary excretion of carbamoyl glucuronide DOI:10.1248/bpb.30.1580
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