| Identification | Back Directory | [Name]
UC-1728 (Synonyms: t-TUCB) | [CAS]
948304-40-3 | [Synonyms]
UC-1728
t-TUCB.
t-TUCB
UC-1728
UC-1728 (t-TUCB)
UC-1728 (Synonyms: t-TUCB)
UC-1728; UC 1728; UC1728; T-TUCB.
Benzoic acid, 4-[[trans-4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]- | [Molecular Formula]
C21H21F3N2O5 | [MDL Number]
MFCD31807631 | [MOL File]
948304-40-3.mol | [Molecular Weight]
438.4 |
| Chemical Properties | Back Directory | [Melting point ]
244-273 °C(Solv: methanol (67-56-1)) | [Boiling point ]
536.4±50.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:43.84(Max Conc. mg/mL);100.0(Max Conc. mM) | [form ]
Solid | [pka]
4.45±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UC-1728 is a potent rabbit soluble epoxide hydrolase (sEH) inhibitor, with an IC50 of 2 nM on rabbit liver. | [in vivo]
Miotic, fixed pupils are observed in the treated eyes of both groups receiving LPS injections but the difference in pupillary light reflex scores is only significantly increased in the UC-1728/LPS treated group relative to the PBS group at 6 h post-injection[1]. Pretreatment with UC-1728 (t-TUCB) at 10 and 30 mg/kg, p.o., significantly prevents ISO induced increase in heart weight and elevation of CK-MB and LDH levels (p<0.05), indicating its cardioprotective effect against ISO induced cardiac injury. At 3 mg/kg, p.o. UC-1728 only shows significant protection against heart weight changes. Pretreatment with UC-1728 at 3, 10 and 30 mg/kg, p.o., significantly reduces the ISO induced infarct size (p<0.05) when compared to control. The calculated percentage reductions for these doses are found to by 15.90, 46.60 and 40.44%, respectively[2]. Inhibition of sEH with UC-1728 is associated with a significant improvement in pain scores in one horse with laminitis whose pain is refractory to the standard of care therapy. No adverse effects are noticed[3]. | [storage]
Store at -20°C | [References]
[1] McLellan GJ, et al. Effect of a Soluble Epoxide Hydrolase Inhibitor, UC1728, on LPS-Induced Uveitis in the Rabbit. J Ocul Biol. 2016 Jan;4(1). DOI:10.13188/2334-2838.1000024. doi: 10.13188/2334-2838.1000024
[2] Shrestha A, et al. Soluble epoxide hydrolase inhibitor, t-TUCB, protects against myocardial ischaemic injury in rats. J Pharm Pharmacol. 2014 Sep;66(9):1251-8. DOI:10.1111/jphp.12251
[3] Guedes AG, et al. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg. 2013 Jul;40(4):440-8. DOI:10.1111/vaa.12030 |
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