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948845-91-8

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948845-91-8 Structure

948845-91-8 Structure
IdentificationBack Directory
[Name]

3(2H)-Pyridazinone, 2-[4'-[(3aR,6aR)-hexahydro-5-methylpyrrolo[3,4-b]pyrrol-1(2H)-yl][1,1'-biphenyl]-4-yl]-
[CAS]

948845-91-8
[Synonyms]

ABT288
ABT-288
ABT 288
3(2H)-Pyridazinone, 2-[4'-[(3aR,6aR)-hexahydro-5-methylpyrrolo[3,4-b]pyrrol-1(2H)-yl][1,1'-biphenyl]-4-yl]-
[Molecular Formula]

C23H24N4O
[MOL File]

948845-91-8.mol
[Molecular Weight]

372.46
Chemical PropertiesBack Directory
[Boiling point ]

567.4±60.0 °C(Predicted)
[density ]

1.26±0.1 g/cm3(Predicted)
[pka]

9.78±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

ABT-288 is a competitive, potent and selective histamine H3 receptor (H3R) antagonist. ABT-288 has Ki values of 1.9 and 8.2 nM for human and rat H3Rs, respectively. ABT-288 can be used in cognitive impairment research.[1].
[IC 50]

human H3 receptor: 1.9 nM (Ki); rat H3 receptor: 8.2 nM (Ki)
[References]

[1] Esbenshade TA, et al. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist. J Pharmacol Exp Ther. 2012 Oct;343(1):233-45. DOI:10.1124/jpet.112.194126
Spectrum DetailBack Directory
[Spectrum Detail]

3(2H)-Pyridazinone, 2-[4'-[(3aR,6aR)-hexahydro-5-methylpyrrolo[3,4-b]pyrrol-1(2H)-yl][1,1'-biphenyl]-4-yl]-(948845-91-8)1HNMR
948845-91-8 suppliers list
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Telephone: 021-65675885 18964387627
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Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
Company Name: Shanghai Amole Biotechnology Co., Ltd.  
Telephone: 13370042665 18916960931
Website: www.amole.com.cn/
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