| Identification | Back Directory | [Name]
HUMAN TNF-ALPHA | [CAS]
94948-59-1 | [Synonyms]
hTNF-α
CACHECTIN
HUMAN DIF
TNF ALPHA
HTNF-ALPHA
Tasonermin
TNF, HUMAN
HUMAN TNF-A
RHTNF-ALPHA
RH-CACHECTIN
HUMAN TNFSF2
HUMAN NECROSIN
HUMAN CACHECTIN
HUMAN CYTOTOXIN
HUMAN TNF-ALPHA
TNFSF 2 (HUMAN)
TNF-ALPHA HUMAN
RHSMEGA-TNF-ALPHA
REC TNF-A (HUMAN)
rec TNF-α (human)
REC TNF-ALPHA (HUMAN)
RECOMBINANT HUMAN TNF-A
TNFSF 2, SOLUBLE (HUMAN)
TNF-α, Human, Recombinant,
TNF-ALPHA, SOLUBLE (HUMAN)
TUMOR NECROSIS FACTOR-ALPHA
tumor necrosis factor-α human
TNF-ALPHA, HUMAN E COLI, R-DNA
Tumor Necrosis Factor-α, human
TNF-ALPHA, SOLUBLE (HUMAN) (REC)
EXTRACELLULAR DOMAIN (AA 85-233)
HUMAN TNF-ALPHA (E COLI-DERIVED)
HUMAN TUMOR NECROSIS FACTOR ALPHA
TNF-α, Human, Recombinant, E. coli
TUMOR NECROSIS FACTOR-ALPHA, HUMAN
HUMAN DIFFERENTIATION-INDUCING FACTOR
REC TUMOR NECROSIS FACTOR-ALPHA (HUMAN)
TUMOR NECROSIS FACTOR(TNF)-ALPHA, HUMAN
TNF-ALPHA, SOLUBLE (HUMAN) (RECOMBINANT)
recombinanthumantumornecrosisfactoralpha
humanrecombinanttumornecrosisfactor-alpha
Tumor Necrosis Factor-α human,TNF-α, hTNF-α
RECOMBINANT HUMAN TNF-ALPHA (E COLI-DERIVED)
TUMOR NECROSIS FACTOR-ALPHA, SOLUBLE (HUMAN)
Tumor Necrosis Factor-α Human recombinant
TUMOR NECROSIS FACTOR-ALPHA, HUMAN, RECOMBINANT
tumor necrosis factor human recombinant produced
TUMOR NECROSIS FACTOR, ALPHA-, HUMAN E COLI, R-DNA
TUMOR NECROSIS FACTOR HUMAN RECOMBINANT PRODUCED IN
TUMOR NECROSIS FACTOR-A, HUMAN*RECOMBINA NT, EXPRESS
TUMOR NECROSIS FACTOR(TNF)-ALPHA, HUMAN, RECOMBINANT
N-Propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carbo xamide - 2,4,7-trinitro-9H-fluoren-9-one (1:1) | [Molecular Formula]
NULL | [MDL Number]
MFCD00148692 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [form ]
powder | [color ]
colorless | [biological source]
human | [Water Solubility ]
distilled water: 0.1—1mg/mL | [Specific Activity]
≥2 * 107U/mg |
| Hazard Information | Back Directory | [Description]
Tasonermin was launched in Germany for the treatment of
soft tissue sarcoma of the limbs. Recent literature is scarce for this compound. It
is the first tumor necrosis factor (TNF) launched for cancer treatment to date and
works through destruction of tumor blood vessels. This recombinant protein is
expressed in E. coil and purified. Tasonermin is too toxic for systemic use and
consequently is being used in isolated limb perfusion (ILP) for sarcoma and
malignant melanoma. The product has shown notable efficacy when used in
combination with melphalan to prevent amputation. In four European clinical
trials involving 260 patients destined for amputation or mutilating surgery,
Beromun enabled durable limb salvage in 80% of the patients. Due to the
complexity of ILP, the application of tasonermin is restricted to clinical centers
with sufficient experience and facilities including radionucleide-based continuous
monitoring of leakage from the isolated circuit during ILP and postoperative
intensive care surveillance. | [Originator]
Genentech (US) | [Uses]
TNF-α include stimulating growth of human fibroblasts and other cell lines activating polymorphonuclear neutrophils and osteoclasts and inducing interleukin-1, prostaglandin E2, and collagenase production. | [Uses]
Tumor Necrosis Factor-a human has been used:
- as a permeability inducing agent for endothelial cell monolayer permeability assay
- as a reactive oxygen species inducer in primary rat cardiac microvascular endothelial cells (RCMVECs)
- in the activation of nuclear factor kappa B (NF-κB) in human embryonic kidney cells (HEK293), neuroblastoma SH-SY5Y cells and HeLa cells
- in the stimulation of the human keratinocyte cell line(HaCaT) and human coronary artery endothelial cells (HCAECs)
| [Brand name]
Beromun | [General Description]
The TNFα (tumor necrosis factor α) gene is mapped to human chromosome 6p21.33. TNFα is a member of TNF superfamily. TNF-α has a palmitoyl group in the cysteine residue and is phosphorylated in the transmembrane region serine residue. | [Biochem/physiol Actions]
Tumor Necrosis Factor-α (TNF-α) is a potent pro-inflammatory cytokine that plays a role in the rheumatoid arthritis pathology, psoriatic arthritis (PsA) and psoriasis. It stimulates interleukins IL-1 and IL-6. Polymorphism in the TNF-α gene is associated with destructive arthropathy in PsA. The post-translational modifications in TNF-a is crucial for its functionality. |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
amyjetsci
|
| Tel: |
027-59626688 18771149750 |
| Website: |
https://www.amyjet.com/ |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|