| Identification | Back Directory | [Name]
4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE | [CAS]
95-02-3 | [Synonyms]
Grewe DiaMine
5-Aminomethyl-2-methyl-4-pyrimidineamine
4-amino-2-methylpyrimidine-5-methylamine
2-methyl-4-amino-5-aminomethylpyrimidine
2-Methyl-4-aminopyrimidine-5-methanamine
2-Methyl-5-(aminomethyl)-4-pyrimidinamine
5-PyriMidineMethanaMine,4-aMino-2-Methyl-
5-(Aminomethyl)-4-amino-2-methylpyrimidine
(4-amino-2-methyl-pyrimidin-5-yl)methylamine
5-Pyrimidinemethanamine, 4-amino-2-methyl- (9CI)
4-Amino-5-aminomethyl-2-methylpyrimidine hydrochloride
4-Amino-2-methyl-5-pyrimidinemethanamine,dihydrochlorine
4-AMINO-2-METHYL-5-PYRIMIDINEMETHANAMINE, DIHYDROCHLORIDE
4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE | [EINECS(EC#)]
202-384-7 | [Molecular Formula]
C6H12Cl2N4 | [MDL Number]
MFCD00058194 | [MOL File]
95-02-3.mol | [Molecular Weight]
211.09 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
270-272°C | [Boiling point ]
121-125 °C | [density ]
1.207 | [vapor pressure ]
0.012-0.019Pa at 20-25℃ | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) | [form ]
Solid | [pka]
7.70±0.29(Predicted) | [color ]
Off-White to Beige | [PH]
10.65 at 20℃ and 10g/L | [InChI]
InChI=1S/C6H10N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,2,7H2,1H3,(H2,8,9,10) | [InChIKey]
OZOHTVFCSKFMLL-UHFFFAOYSA-N | [SMILES]
C1(C)=NC=C(CN)C(N)=N1 | [LogP]
-2.27 at 20℃ and pH7 | [Surface tension]
72.77mN/m at 1g/L and 20℃ |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Substrate for TenA enzyme in the thiamin salvage pathway | [Definition]
ChEBI: An aminopyrimidine compound having its amino substituent at the 4-position together with methyl and aminomethyl substituents at the 2- and 5-positions respectively. | [Synthesis]
In an autoclave, the mixture of 4-Amino-5-aminomethyl-2-methylpyrimidine (2.0 kg, 15 mol), modified Raney nickel (wet weight 300 g), and saturated methanol solution of ammonia (20 L) was heated to 100 ℃ and stirred for 5 h at this temperature under 4 MPa hydrogen pressure. Then, the mixture was cooled to room temperature and filtered; 4-Amino-5-aminomethyl-2-methyl pyrimidine was obtained as a white solid (2.0 kg, 98%) by concentrating the filtrate[1].
| [References]
[1] Lei Zhao, Fen-Er Chen, Xiao-Dong Ma. “Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1.” Organic Process Research & Development 16 1 (2011): 57–60.
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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