| Identification | Back Directory | [Name]
TTP-8307 | [CAS]
950225-08-8 | [Synonyms]
TTP-8307
Benzamide, N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[2-(3-isoquinolinyl)-1H-imidazol-5-yl]- | [Molecular Formula]
C27H21FN4O | [MDL Number]
MFCD32858257 | [MOL File]
950225-08-8.mol | [Molecular Weight]
436.48 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (229.11 mM) | [form ]
Solid | [color ]
White to light yellow | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP)[1][2]. | [References]
[1] De Palma AM, et al. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. DOI:10.1128/AAC.00934-08
[2] Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 Apr;140:37-44. DOI:10.1016/j.antiviral.2017.01.008 |
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