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95130-23-7

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95130-23-7 Structure

95130-23-7 Structure
IdentificationBack Directory
[Name]

NSC 150117 hydrochloride
[CAS]

95130-23-7
[Synonyms]

(E/Z)-BCI
BCI (hydrochloride)
(E)-BCI hydrochloride
(E/Z)-BCI hydrochloride
NSC 150117 hydrochloride
BCI hydrochloride - NSC 150117 hydrochloride
(2Z)-2-benzylidene-3-(cyclohexylamino)-3H-inden-1-one
2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride
(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one
3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one
[Molecular Formula]

C22H24ClNO
[MDL Number]

MFCD16875416
[MOL File]

95130-23-7.mol
[Molecular Weight]

353.885
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble10mg/mL, clear
[form ]

powder
[color ]

white to beige
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

(E/Z)-BCI hydrochloride has been used:
  • to evaluate the role of the Duox-H2O2-Dusp6 derepression signaling pathway in heart regeneration
  • as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
  • as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells

[Biochem/physiol Actions]

BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.
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