| Identification | Back Directory | [Name]
BETA-D-GLUCOPYRANOSIDURONIC ACID | [CAS]
51059-44-0 | [Synonyms]
Oroxindin
WOGONOSIDE
Glychionide B
Wogonin-7β-glucuronide
Wogonin 7-O-glucuronide
B-D-GLUCOPYRANOSIDURONICACID
wogonin 7-O-beta-D-glucuronide
BETA-D-GLUCOPYRANOSIDURONIC ACID
β-D-Glucopyranosiduronic acid,5-hydroxy-
BETA-D-GLUCOPYRANOSIDURONIC ACID USP/EP/BP
8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl
5,7-Dihydroxy-8-methoxyflavone 7-O-beta-D-Glucuronide
5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-gl...
2-Phenyl-5-hydroxy-7-(β-D-glucopyranuronosyloxy)-8-methoxy-4H-1-benzopyran-4-one
5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid
(5-Hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl)β-D-glucopyranosiduronic acid
β-D-Glucopyranosiduronic acid, 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl
5-Hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-beta-D-glucopyranosiduronic acid
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylicaci
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid
(2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-((5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid | [Molecular Formula]
C6H10O7 | [MDL Number]
MFCD08704808 | [MOL File]
51059-44-0.mol | [Molecular Weight]
194.139 |
| Chemical Properties | Back Directory | [Melting point ]
226-227℃ | [Boiling point ]
820.7±65.0 °C(Predicted) | [density ]
1.629 | [storage temp. ]
?20°C | [solubility ]
DMSO (Slightly), Methanol (Very Slightly) | [form ]
Solid | [pka]
2.73±0.70(Predicted) | [color ]
Pale Yellow | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChIKey]
LNOHXHDWGCMVCO-NTKSAMNMSA-N | [SMILES]
COc1c(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc(O)c3C(=O)C=C(Oc13)c4ccccc4 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Scutellaria baicalensis. | [Uses]
Wogonoside is a flavonoid present in extracts from plant Radic scutellariae and provides antioxidant activity. | [Definition]
ChEBI: The glycosyloxyflavone which is the 7-O-glucuronide of wogonin. | [General Description]
Natural product derived from plant source. | [Biochem/physiol Actions]
Wogonoside, a flavanoid, is known for its anti-inflammatory properties. Wogonoside may have therapeutic potential for use in diseases which involve the development of inflammation and angiogenesis through its inhibition of LPS-induced angiogenesis. | [in vivo]
Wogonoside (80 mg/kg, oral gavage, once every other day) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic model[3].
Wogonoside (40 or 80 mg/kg, i.p., every three days) inhibits tumor growth and reduces Bcl-2/Bax ratio in A549 cell xenograft mice[4].
Wogonoside (80 mg/kg, i.P., every other day for 14 days) also inhibits tumor growth in U937 xenograft model[5].
| Animal Model: | MDA-MB-231 orthotopic model[3] | | Dosage: | 80 mg/kg | | Administration: | oral gavage, once every other day | | Result: | Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone.
Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at ?orthotopic site. |
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