| Identification | Back Directory | [Name]
Perindoprilat | [CAS]
95153-31-4 | [Synonyms]
S-9780
Diacid form
PERINDOPRILAT
Perindoprilat ,95%
PERINDOPRILAT HYDRATE
Perindopril Impurity 5
Perindopril EP IMpurity B
Perindopril Related CoMpound B
Perindopril EP IMpurity-B(USP RC B)
Perindopril impurity Ⅲ(Perindoprilat)
Perindoprilat (Mixture of Diastereomers)
(2s-(1(r*(r*)),2-alpha,3a-beta,7a-beta))-)
1h-indole-2-carboxylicacid,octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl
(2S,3AS,7aS)-1-((S)-2-(((S)-1-carboxybutyl)amino)propanoyl)octahydro-1H-indole-2-carboxylic ac
(2S,3aS,7aS)-1-[(S)-2-[[(S)-1-Carboxybutyl]amino]-1-oxopropyl]hexahydroindoline-2-carboxylic acid
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]aMino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid
1H-Indole-2-carboxylicacid, 1-[(2S)-2-[[(1S)-1-carboxybutyl]aMino]-1-oxopropyl]octahydro-,(2S,3aS,7aS)-
[2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)aMino]-1-
oxopropyl]octahydro-1H-indole-2-carboxylic Acid
(2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-Carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Perindopril Related Compound B (10 mg) ((2S,3aS,7aS)-1-{(S)-2-[(S)-1-carboxybutylamino]propanoyl}octahydro-1H-indole-2-carboxylic acid) | [Molecular Formula]
C17H28N2O5 | [MDL Number]
MFCD00865777 | [MOL File]
95153-31-4.mol | [Molecular Weight]
340.41 |
| Chemical Properties | Back Directory | [Appearance]
White to Off-White Solid | [Melting point ]
153-155°C | [Boiling point ]
568.1±45.0 °C(Predicted) | [density ]
1.222±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
2.27±0.20(Predicted) | [color ]
White to Pale Beige | [Stability:]
Hygroscopic | [CAS DataBase Reference]
95153-31-4 |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive. | [Uses]
Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical] | [Definition]
ChEBI:Perindoprilat is a dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a drug metabolite. It is an organic heterobicyclic compound, a dipeptide, a dicarboxylic acid and a L-alanine derivative. | [storage]
Store at -20°C |
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