| Identification | More | [Name]
Pyruvic acid | [CAS]
127-17-3 | [Synonyms]
2-KETOPROPANOIC ACID
2-KETOPROPIONIC ACID
2-OXOPROPANOIC ACID
2-OXOPROPIONIC ACID
ACETYLFORMIC ACID
ALPHA-KETOPROPIONIC ACID
FEMA 2970
PYRORACEMIC ACID
PYRUVIC ACID
RARECHEM AL BO 1238
2-oxo-propanoicaci
CH3COCOOH
Propanoic acid, 2-oxo-
Propanoicacid,2-oxo-
pyruvic
PYRUVIC ACID 99%
PYRUVIC ACID FREE ACID MINIMUM 90%*(ENZY MATIC ASSAY
PYRUVIC ACID 80+% NATURAL
PYRUVIC ACID 97+%
PYRUVIC ACID FREE ACID 65-80% | [EINECS(EC#)]
204-824-3 | [Molecular Formula]
C3H4O3 | [MDL Number]
MFCD00002585 | [Molecular Weight]
88.06 | [MOL File]
127-17-3.mol |
| Chemical Properties | Back Directory | [Definition]
A fundamen-
tal intermediate in protein and carbohydrate
metabolism in the cell.
| [Appearance]
Colorless to light yellow liquid | [Melting point ]
11-12 °C (lit.) | [Boiling point ]
165 °C (lit.) | [density ]
1.272 g/mL at 20 °C
| [vapor pressure ]
1.72hPa at 25℃ | [FEMA ]
2970 | [refractive index ]
n20/D 1.428(lit.)
| [Fp ]
183 °F
| [storage temp. ]
2-8°C
| [solubility ]
Miscible with chloroform and methanol. | [form ]
Liquid | [pka]
2.39(at 25℃) | [color ]
Clear colorless to light yellow or amber | [Odor]
at 1.00 % in propylene glycol. sharp sour acetic caramellic | [PH]
1.2 (90g/l, H2O, 20℃) | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. Refrigerate. | [Odor Type]
acidic | [JECFA Number]
936 | [Merck ]
14,8021 | [BRN ]
506211 | [InChIKey]
LCTONWCANYUPML-UHFFFAOYSA-N | [LogP]
-1.24 | [Uses]
pyruvic acid is an alpha hydroxy acid that can be irritating and is considered difficult to work with. It has a larger molecular size than the most commonly used AHAs. Sodium pyruvate is more commonly used, and is an organic salt. | [Dissociation constant]
2.49 at 25℃ | [CAS DataBase Reference]
127-17-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyruvic acid(127-17-3) | [EPA Substance Registry System]
127-17-3(EPA Substance) |
| Questions And Answer | Back Directory | [Uses]
Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.
| [Antioxidant effect]
Studies have shown that pyruvic acid can inhibit the oxidation of oxygen free radicals in mice, and as a hydrogen peroxide scavenger, it has the effect of preventing free radical damage, and it has been proved to be protective in cardiac reperfusion injury and acute renal failure. The body resists functional damage. Pyruvic acid can act as an antioxidant through two mechanisms: first, as an α-keto acid, pyruvic acid can directly inhibit hydrogen peroxide through a non-enzymatic decarbonation reaction; second, supplementation of pyruvic acid can enhance In the citric acid cycle, after the production of citric acid increases, the phosphofructokinase is inhibited, thereby entering the pentose phosphate bypass to generate reduced coenzyme II (NADPH), thereby indirectly increasing the ability of the glutathione (GSH) antioxidant system. Pyruvic acid can also increase the ratio of coenzyme I/reduced coenzyme I (NAD+/NADH) and promote the reaction of the tricarboxylic acid cycle. |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
UZ0829800
| [Autoignition Temperature]
305 °C | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29335995 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liquid | [Chemical Properties]
Pyruvic acid has a sour, acetic odor (similar to acetic acid). It has a pleasant, sour taste with a burning, somewhat sweet note. It tends to darken and decompose unless kept free of minor contaminants and in tightly sealed containers | [Occurrence]
Isolated from cane sugar fermentation broth and from a few plants; also reported found in peppermint, raw asparagus, leaves and stalk of celery, onion, rutabaga, milk, cream, buttermilk, wheaten bread, blue cheeses, cheddar cheese, cottage cheese, provolone cheese, yogurt, beef, Virginia tobacco, beer, white wine, botrytised wine, cocoa and sake. | [Preparation]
By distillation of tartaric acid in the presence of potassium acid sulfate as a dehydrating agent; from acetyl chloride and potassium cyanide to yield the nitrile, which is subsequently acid hydrolyzed to the acid; pyruvic acid must be rectified under vacuum. | [Aroma threshold values]
Aroma characteristics at 1.0%: acidic, sweet, caramellic and sour. | [Taste threshold values]
Taste characteristics at 5 ppm: sharp acidic, sour fruity, with sour creamy and caramellic nuances. | [General Description]
Pyruvic acid is the key component formed during the hydrolysis of flavor-precursors called S-alk(en)yl-L-cysteine-sulfoxides in onion tissues by allinase during maceration or chopping. The amount of pyruvic acid formed is used as a measure for onion pungency. | [Biochem/physiol Actions]
Taste at 5 ppm | [Biotechnological Applications]
Pyruvic acid is a key position in cell metabolism and is involved in many catabolic and anabolic pathways, including glycolysis, gluconeogenesis, amino acid, and protein metabolism. Pyruvic acid is employed for the production of L-tryptophan, L-tyrosine, and 3,4-dihydroxyphenyl alanine in various industries. The diet supplementation with pyruvic acid increased fat loss and minimized the associated loss of body protein. Pyruvic acid is also used in biochemical researches and medicine as a substrate for assaying activities of such enzymes as pyruvate dehydrogenase, pyruvate carboxylase, and pyruvate decarboxylase (Nakazawa et al. 1972; Yamada et al. 1972; Stanko et al. 1992).
Y. lipolytica oxidize glucose and form pyruvic acid (75–80 %) and a-ketoglutaric acid (20–25 %) under thiamine deficiency conditions. The synthesis of the acid was triggered by a decrease in intracellular thiamine concentration to 3.0 lg per 1 g biomass. An approximately 3-fold increase in the amount of the biomass was associated with a subsequent decrease in thiamine content to the level of 1.0 lg per 1 g biomass, whose maximum production of pyruvic acid was 50 g/L in this condition. In addition to glucose, thiamine-auxotrophic yeasts are capable of synthesizing pyruvic acid when grown on glycerol and propionic acid. Technicalgrade glycerol is the most promising raw material for pyruvic acid production. Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005). | [Purification Methods]
Distil it twice, then fractionally crystallise it by partial freezing. [Beilstein 3 IV 1505.] |
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