| Identification | Back Directory | [Name]
4-[(3AR,4S,9BS)-6-ETHOXY-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA[C]QUINOLIN-4-YL]BENZOIC ACID | [CAS]
956189-58-5 | [Synonyms]
LIN28 inhibitor LI71 enantiomer
4-[(3AR,4S,9BS)-6-ETHOXY-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA[C]QUINOLIN-4-YL]BENZOIC ACID | [Molecular Formula]
C21H21NO3 | [MDL Number]
MFCD07403664 | [MOL File]
956189-58-5.mol | [Molecular Weight]
335.4 |
| Hazard Information | Back Directory | [Uses]
LIN28 inhibitor LI71 enantiomer is the enantiomer of LIN28 inhibitor LI71 with less active. LIN28 inhibitor LI71 is a potent and cell-permeable LIN28 inhibitor, which abolishes LIN28-mediated oligouridylation with an IC50 of 7 uM[1]. | [References]
[1] Wang L, et al. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Rep. 2018;23(10):3091-3101. DOI:10.1016/j.celrep.2018.04.116 |
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