| Identification | Back Directory | [Name]
XL147 | [CAS]
956958-53-5 | [Synonyms]
XL147
CS-36
SAR245408
XL147;XL 147
XL147, >=98%
XL147 ANALOG
XL147 analogue
PI3K inhibitorX
XL147 ANALOG 1G
XL147 USP/EP/BP
XL-147(SAR245408)
SAR245408 (XL-147)
XL147;XL-147;SAR245408
XL147 analogue(PI3K inhibitor X)
N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide
N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide,
Benzenesulfonamide, N-[3-(2,1,3-benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methyl-
N-[3-(Benzo[c][1,2,5]thiadiazol-5-ylaMino)quinoxalin-2-yl]-4-MethylbenzenesulfonaMide
N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methylbenzenesulfonamide XL 147
N-(3-(Benzo[c][1,2,5]thiadiazol-5-ylamino)quinoxalin-2-yl)-4-methylbenzenes ulfonamide | [Molecular Formula]
C21H16N6O2S2 | [MDL Number]
MFCD16621245 | [MOL File]
956958-53-5.mol | [Molecular Weight]
448.521 |
| Chemical Properties | Back Directory | [Boiling point ]
638.9±65.0 °C(Predicted) | [density ]
1.538 | [storage temp. ]
Store at -20°C | [solubility ]
≥22.45 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH | [form ]
solid | [pka]
6.71±0.30(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
XL147 analog is an analog of XL147 (Item No. 18011). | [Uses]
XL147 analogue is one of Pyrimidine derivatives as JAK-2 inhibitors in combination with other agents and their use in the treatment of diseases.
| [Definition]
ChEBI:XL147 is a sulfonamide that is the N-4-toluenesulfonyl (N-tosyl) derivative of N-(2,1,3-benzothiadiazol-5-yl)quinoxaline-2,3-diamine. A selective PI3K inhibitor used in cancer treatment. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an antineoplastic agent. It is a sulfonamide, a quinoxaline derivative, a benzothiadiazole and an aromatic amine. | [target]
PI3Kα | [IC 50]
PI3K-alpha | [storage]
Store at -20°C |
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