| Identification | Back Directory | [Name]
SID 26681509 | [CAS]
958772-66-2 | [Synonyms]
ML023
SID 26681509
SID26681509; SID-26681509
N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
S-[2-[(2-ethylphenyl)amino]-2-oxoethyl] [2-[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]hydrazinyl]methanethioate | [Molecular Formula]
C27H33N5O5S | [MDL Number]
MFCD16875433 | [MOL File]
958772-66-2.mol | [Molecular Weight]
539.65 |
| Hazard Information | Back Directory | [Uses]
SID 26681509 is a small molecule cathespin L inhibitor. | [Definition]
ChEBI: SID 26681509 is a carbohydrazide that is L-tryptophan in which the amino and carboxy groups are substituted by tert-butoxycarbonyl and 2-({[2-(2-ethylanilino)-2-oxoethyl]sulfanyl}carbonyl)hydrazinyl groups, respectively. It is a potent and reversible inhibitor of human cathepsin L (IC50 = 56 nM). It has a role as a cathepsin L (EC 3.4.22.15) inhibitor and an antiplasmodial drug. It is a secondary carboxamide, a L-tryptophan derivative, a tert-butyl ester, a thioester and a carbohydrazide. | [Biological Activity]
sid 26681509 is a potent and reversible human cathepsin l inhibitor.the cathepsins have been found to comprise a family of lysosomal protease enzymes whose primary functions, such as protein degradation, play a keyl role in normal cellular homeostasis. overexpression of cathepsin l and/or abnormal activity has been implicated in a number of disease states. | [in vitro]
sid 26681509 was found to inhibit human cathepsin l with an ic50 of 56 nm. after preincubation with enzyme for 1, 2, and 4 h before substrate addition, sid 26681509 showed increasing potency, with ic50 values falling to 7.5, 4.2, and 1.0 nm, respectively, indicating a slow onset of inhibition. sid 26681509 was also observed to be nontoxic to human aortic endothelial cells up to 100 μm. sid 26681509 was active in an in vitro propagation assay against p. falciparum with an ic50 of 15.4 μm. additionally, the thiocarbazate inhibitor was toxic toward l. major promastigotes with an ic50 of 12.5 μm [1]. | [in vivo]
sid 26681509 showed a lack of toxicity to zebrafish in a live organism assay at 100 μm [1]. | [IC 50]
56 nm | [storage]
Store at -20°C | [References]
[1] shah pp,myers mc,beavers mp,purvis je,jing h,grieser hj,sharlow er,napper ad,huryn dm,cooperman bs,smith ab 3rd,diamond sl. kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin l. mol pharmacol.2008 jul;74(1):34-41. |
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