| Identification | Back Directory | [Name]
2-N-HEXYL-4-PENTYNOIC ACID | [CAS]
96017-59-3 | [Synonyms]
Hexyl-4-pentynoic Acid
2-PROPARGYLOCTANOIC ACID
2-Hexyl-4-pentynoic Acid
2-N-HEXYL-4-PENTYNOIC ACID
2-Hexyl-4-pentynoicAcid>
2-(2-PROPYNYL)OCTANOIC ACID
Hexyl-4-pentynoic acid (HPA)
R-2-(2-propynyl)octanoic acid
2-(Prop-2-yn-1-yl)octanoic acid
2-Propargyloctanoic Acid
2-(2-Propynyl)octanoic Acid
HDAC inhibitor,Heat shock proteins,HSP70,Excitotoxicity,Histone deacetylases,inhibit,HDAC,Neuroprotection,2hexyl4Pentynoic Acid,2 hexyl 4 Pentynoic Acid,Inhibitor,Glutamate,HSP,Valproic acid | [Molecular Formula]
C11H18O2 | [MDL Number]
MFCD00946863 | [MOL File]
96017-59-3.mol | [Molecular Weight]
182.26 |
| Chemical Properties | Back Directory | [Boiling point ]
287.1±23.0 °C(Predicted) | [density ]
0.94 | [refractive index ]
1.4450-1.4510 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). | [form ]
oil | [pka]
4.24±0.21(Predicted) | [color ]
Colorless | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| Hazard Information | Back Directory | [Description]
2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM. | [Uses]
2-Hexyl-4-pentynoic acid ((±)-2-Hexyl-4-pentynoic acid), valproic acid (VPA) derivative, exhibits potential roles of HDAC inhibition (IC50=13 μM) and HSP70 induction. Potent neuroprotective effects. 2-Hexyl-4-pentynoic acid causes histone hyperacetylation and protect against glutamate-induced excitotoxicity in cultured neurons[1]. 2-Hexyl-4-pentynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272
2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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