| Identification | Back Directory | [Name]
ε-N-Deoxyfructosyllysine dihydrochloride | [CAS]
96192-35-7 | [Synonyms]
Fructosyl-lysine dihydrochloride | [Molecular Formula]
C12H25ClN2O7 | [MDL Number]
MFCD32874155 | [MOL File]
96192-35-7.mol | [Molecular Weight]
344.79 |
| Hazard Information | Back Directory | [Uses]
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection[1]. | [in vivo]
Fructosyl-lysine dihydrochloride and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1]. | [References]
[1] Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11. DOI:10.2337/db14-1516
[2] Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5. DOI:10.1042/bst0311423 |
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