| Identification | Back Directory | [Name]
1-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-phenyl-6-isoquinolinol | [CAS]
96719-63-0 | [Synonyms]
1-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-phenyl-6-isoquinolinol | [Molecular Formula]
C21H18FNO | [MOL File]
96719-63-0.mol | [Molecular Weight]
319.37 |
| Chemical Properties | Back Directory | [Boiling point ]
496.0±45.0 °C(Predicted) | [density ]
1.236±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
9.91±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Estrogen receptor modulator 11 (Compound 27) is a tetrahydroisoquinoline derivative. Estrogen receptor modulator 11 has a certain affinity for estrogen receptors (ER), with IC50 values of 285 nM and 421 nM for ERα and ERβ, respectively. Estrogen receptor modulator 11 lacks antagonist activity in the MCF-7 cellular assay[1]. | [References]
[1] Renaud J, et al. Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands. J Med Chem. 2003 Jul 3;46(14):2945-57. DOI:10.1021/jm030086h |
|
| Company Name: |
TargetMol
|
| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
|