| Identification | Back Directory | [Name]
tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate | [CAS]
96929-05-4 | [Synonyms]
5-(2-furyl)-1h-indazole
Ethyl 2-(Boc-aminomethyl)thiazole-4-carboxylate
tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate
Ethyl 2-((tert-butoxycarbonyl)-methyl)thiazole-4-carboxylate
Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate
ethyl 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carboxylate
ethyl 2-{[(tert-butoxycarbonyl)aMino]Methyl}-1,3-thiazole-4-carboxylate
2-(((tert-butoxycarbonyl)amino)methyl)-5-ethylthiazole-4-carboxylic acid
2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carboxylic acid ethyl ester
Ethyl 2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-1,3-thiazole-4-carboxylate
4-Thiazolecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, ethyl ester | [Molecular Formula]
C12H18N2O4S | [MDL Number]
MFCD09878704 | [MOL File]
96929-05-4.mol | [Molecular Weight]
286.35 |
| Chemical Properties | Back Directory | [Melting point ]
100-102 °C | [Boiling point ]
401.4±25.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
10.92±0.46(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Method A: 24.6 mmol of ethyl 3-bromopyruvate was slowly added to a 47 mL solution of isopropanol containing 5.0 g (24.2 mmol) of tert-butyl (2-amino-2-thioethyl)carbamate at 20-25 °C. The reaction mixture was stirred continuously at this temperature for 5 hours. Subsequently, 24.0 mmol of a 20% aqueous sodium hydroxide solution was added to the reaction system. Upon completion of the reaction, the organic phase was separated by extraction using methyl tert-butyl ether. The organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 6.2 g of ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate in 89.6% yield. The product was characterized by 1H-NMR (DMSO-d6, ppm): 8.41 (s, 1H, Ar-H), 7.86 (t, br, NH), 4.41 (d, 2H, CH2), 4.30 (q, 2H, CH2), 1.40 (s, 9H, tert-butyl), 1.30 (t, 3H, CH3). | [References]
[1] Tetrahedron, 1988, vol. 44, # 18, p. 5833 - 5844
[2] Synlett, 2008, # 15, p. 2379 - 2383
[3] Patent: US6642388, 2003, B1. Location in patent: Page/Page column 9
[4] Tetrahedron, 2018, vol. 74, # 5, p. 549 - 555
[5] Patent: CN103601742, 2016, B. Location in patent: Paragraph 0124-0126 |
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