| Identification | Back Directory | [Name]
Lysophosphatidylethanolamines, egg | [CAS]
97281-40-8 | [Synonyms]
Lysophosphatidylethanolamines, egg
Lyso-phosphatidylethanolamine, LPE (egg
L-α-phosphatidylethanolaMine (Egg, Chicken)
L-α-lysophosphatidylethanolamine (Egg, Chicken)
L-Α-LYSOPHOSPHATIDYLETHANOLAMINE (EGG, CHICKEN)
L-Α-PHOSPHATIDYLETHANOLAMINE (EGG, CHICKEN);EGG PE
L-Α-LYSOPHOSPHATIDYLETHANOLAMINE (EGG, CHICKEN);EGG LYSO PE
L-a-Lysophosphatidylethanolamine (Egg Lyso PE) ex. Egg, 99% | [EINECS(EC#)]
306-540-6 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: Soluble | [form ]
A solid | [color ]
White to off-white | [InChI]
1S/C23H48NO7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(26)29-20-22(25)21-31-32(27,28)30-19-18-24/h22,25H,2-21,24H2,1H3,(H,27,28)/t22-/m1/s1 | [InChIKey]
BBYWOYAFBUOUFP-JOCHJYFZSA-N | [SMILES]
[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Hazard Classifications]
Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 3
Carc. 2
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT RE 1
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated via deacylation of phosphatidylethanolamine by phospholipase A2 (PLA2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 and PD 98059 and the EGFR inhibitor AG-1478 . LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage. Lysophosphatidylethanolamines (egg) is a mixture of lysophosphatidylethanolamines isolated from chicken egg with fatty acyl groups of variable lengths at the sn-1 position and a hydroxy group at the sn-2 position. | [Uses]
Lysophosphatidyletha?nolamines, Egg is a natural Glycerophospholipid. Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states. | [Definition]
ChEBI: 1-stearoyl-sn-glycero-3-phosphoethanolamine is a 1-acyl-sn-glycero-3-phosphoethanolamine in which the acyl group is specified as stearoyl. It has a role as a human metabolite. It is a 1-acyl-sn-glycero-3-phosphoethanolamine and a lysophosphatidylethanolamine 18:0. It is functionally related to an octadecanoic acid. It is a tautomer of a 1-stearoyl-sn-glycero-3-phosphoethanolamine zwitterion. | [References]
[1] ATSUYOSHI NISHINA. Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.[J]. Journal of Lipid Research, 2006, 47 7: 1434-1443. DOI: 10.1194/jlr.m600045-jlr200
[2] KUMIKO MAKIDE . Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol[J]. Prostaglandins & other lipid mediators, 2009, 89 3: Pages 135-139. DOI: 10.1016/j.prostaglandins.2009.04.009
[3] S B RYU. Inhibition of phospholipase D by lysophosphatidylethanolamine, a lipid-derived senescence retardant.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1997, 94 23: 12717-12721. DOI: 10.1073/pnas.94.23.12717 |
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