| Identification | Back Directory | [Name]
5(S),6(R),15(S)-TRIHETE METHYL ESTER | [CAS]
97643-35-1 | [Synonyms]
lipoxin A methyl ester
Lipoxin A4 Methyl Ester Solution
5(S),6(R)-LIPOXIN A4 METHYL ESTER
5(S),6(R),15(S)-TRIHETE METHYL ESTER
5S,6R,15S-TRIHYDROXY-7E,9E,11Z,13E-EICOSATETRAENOIC ACID, METHYL ESTER
7,9,11,13-Eicosatetraenoic acid, 5,6,15-trihydroxy-, methyl ester, (5S,6R,7E,9E,11Z,13E,15S)- | [Molecular Formula]
C21H34O5 | [MDL Number]
MFCD05863930 | [MOL File]
97643-35-1.mol | [Molecular Weight]
366.49 |
| Chemical Properties | Back Directory | [Boiling point ]
540.2±50.0 °C(Predicted) | [density ]
1.056±0.06 g/cm3(Predicted) | [Fp ]
10℃ (tag closed test) | [storage temp. ]
Store at -80°C | [solubility ]
DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml | [pka]
13.38±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes. LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM. LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion. | [Uses]
Lipoxin A4 methyl ester is a stable synthetic analog of lipoxin with anti-inflammatory properties that can be extracted from arachidonic acid[1]. | [References]
[1] Xi-Hong Ye, et al. Lipoxin A4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion. Brain Res. 2010 Apr 6:1323:174-83. DOI:10.1016/j.brainres.2010.01.079 |
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