| Identification | Back Directory | [Name]
2-ACETOXYBENZOIC-3,4,5,6-D4 ACID | [CAS]
97781-16-3 | [Synonyms]
Aspro-d
Aspro-D4)
Aspirin-d4
Angettes-d4
Acylpyrin-d4
Acetylsalicylic Acid-D4
2-Acetoxybenzoic-d4 Acid
2-ACETOXYBENZOIC-3,4,5,6-D4 ACID | [Molecular Formula]
C9H4D4O4 | [MDL Number]
MFCD06658866 | [MOL File]
97781-16-3.mol | [Molecular Weight]
184.18 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
131-1330C | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Analgesic; antipyretic; anti-inflammatory; antithrombotic | [Uses]
Labeled Aspirin, intended for use as an internal standard for the quantification of Aspirin by GC- or LC-mass spectrometry. | [Description]
Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS. Aspirin is a non-selective, irreversible COX inhibitor. The IC50 values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition. | [References]
[1] BYRON CRYER MD Mark F M. Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs[J]. American Journal of Medicine, 1998, 104 5: Pages 413-421. DOI: 10.1016/s0002-9343(98)00091-6
[2] JENNIFER L. JOHNSON . Purification and Characterization of Prostaglandin H Synthase-2 from Sheep Placental Cotyledons[J]. Archives of biochemistry and biophysics, 1995, 324 1: Pages 26-34. DOI: 10.1006/abbi.1995.9934
[3] J PAPP. Antiplatelet effect of acetylsalicylic acid, metamizole and their combination - in vitro and in vivo comparisons.[J]. Clinical hemorheology and microcirculation, 2014, 56 1: 1-12. DOI: 10.3233/ch-2012-1636
[4] SHAWN N WHITEHEAD. Effects of triflusal and aspirin in a rat model of cerebral ischemia.[J]. Stroke, 2007, 38 2: 381-387. DOI: 10.1161/01.str.0000254464.05561.72
[5] T. CYRUS. Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice[J]. Circulation: Journal of the American Heart Association, 2002, 88 1: 1282-1287. DOI: 10.1161/01.cir.0000027816.54430.96 |
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TOSUN PHARM
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020-61855200 13326451905 |
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www.toref.cn/ |
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