| Identification | More | [Name]
O-ACETYLSALICYLOYL CHLORIDE | [CAS]
5538-51-2 | [Synonyms]
2-ACETOXYBENZOYL CHLORIDE
ACETYLSALICYLOYL CHLORIDE
AKOS BBS-00003925
ASPIRIN CHLORIDE
O-ACETYLSALICYLOYL CHLORIDE
2-(acetyloxy)-benzoylchlorid
2-(Chlorocarbonyl)phenyl acetate
Acetylsalicoyl chloride
Benzoyl chloride, 2-(acetyloxy)-
O-Acetoxybenzoylchloride
o-Acetylsalicoyl chloride
O-Acetylsalicylryl chloride
O-Acetylsalicyloylchloride,98%
2-ACETYLSALICYLOYL CHLORIDE
o-Acetylsalicychloride
O-Acetylsalicyloyl chloride 97%
2-(acetyloxy)-benzoyl chloride
2-Acetoxybenzoic acid chloride
2-Acetyloxybenzoic acid chloride | [EINECS(EC#)]
226-899-1 | [Molecular Formula]
C9H7ClO3 | [MDL Number]
MFCD00000663 | [Molecular Weight]
198.6 | [MOL File]
5538-51-2.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to light orange chunks | [Melting point ]
45-49 °C (lit.) | [Boiling point ]
107-110 °C/0.1 mmHg (lit.) | [density ]
1.3219 (rough estimate) | [refractive index ]
n20/D 1.536(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
powder to lump | [color ]
White to Orange to Green | [Water Solubility ]
Soluble in toluene. Reacts with water. | [Sensitive ]
Moisture Sensitive | [BRN ]
880372 | [Stability:]
Moisture Sensitive | [InChI]
1S/C9H7ClO3/c1-6(11)13-8-5-3-2-4-7(8)9(10)12/h2-5H,1H3 | [InChIKey]
DSGKWFGEUBCEIE-UHFFFAOYSA-N | [SMILES]
CC(=O)Oc1ccccc1C(Cl)=O | [CAS DataBase Reference]
5538-51-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetylsalicyloyl chloride(5538-51-2) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS05 | [Signal word ]
Danger | [Hazard statements ]
H314 | [Precautionary statements ]
P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | [Hazard Codes ]
C,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R34:Causes burns.
R37:Irritating to the respiratory system.
R29:Contact with water liberates toxic gas. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [F ]
3-10-21 | [Hazard Note ]
Irritant/Corrosive/Moisture Sensitive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29163900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Eye Dam. 1
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
yellow to light orange chunks | [Uses]
O-Acetylsalicyloyl chloride was used in the synthesis of enantiomerically pure bidentate heteroorganic ligands built on simple achiral skeletons and containing an aziridine moiety. It was used in the general synthesis of acetoxybenzamides. It was used in the chemical synthesis of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)-aspirin conjugate via condensation reaction with 4-hydroxy-TEMPO. It was used as reagent in acylation of cyclobutenediones. | [Purification Methods]
Check first the IR to see if an OH frequency is present. If so, some free acid is present. Then reflux with acetyl chloride for 2-3hours and fractionate at high vacuum. The distillate should crystallise. It can be recrystallised from hexane or *C6H6 (m 60o, sintering at 52o). [Riegel & Wittcoff J Am Chem Soc 64 486 1942, Beilstein 10 H 86, 10 I 43, 10 II 55, 10 III 151, 10 IV 169.] |
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Energy Chemical
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China Langchem Inc.
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