Back to ChemicalBook Home--->CAS DataBase List--->98001-69-5

98001-69-5

98001-69-5 Structure

98001-69-5 Structure
IdentificationBack Directory
[Name]

protamine sulfate
[CAS]

98001-69-5
[Synonyms]

PROTAMINE SULFATE
protamine sulfate USP/EP/BP
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

VO9470000
Hazard InformationBack Directory
[Uses]

Antidote (to heparin).
[General Description]

Protamine sulfate has an anticoagulanteffect, but if used in the proper amount, it counteractsthe action of heparin and is used as an antidote for thelatter in cases of overdosage. It is administered intravenouslyin a dose that depends on the circumstances.
[Veterinary Drugs and Treatments]

Protamine is used in all species for the treatment of heparin overdosage when significant bleeding occurs. While protamine will neutralize the anti-thrombin effects of low molecular weight heparins (e.g., dalteparin or enoxaparin), it does not completely inhibit their anti-Xa activity. Laboratory animal studies however, shows it does improve microvascular bleeding associated with LMWH overdoses. Protamine has been suggested for use for Bracken Fern toxicity in ruminants (see Doses).
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