| Identification | Back Directory | [Name]
Adrenalone | [CAS]
99-45-6 | [Synonyms]
u2134
adrenon
stypnon
remestyp
ketogaze
adrenone
chemosan
haemodan
kephrine
stryphnon
styphnone
stryphnone
ADRENALONE
NSC 243611
AKOS NCG-0050
Adrenalone USP/EP/BP
methaminoacetocatechol
Dipivefrine EP Impurity B
4-methylaminoacetocatechol
4-methylaminoacetopyrocatechol
3,4-DIHYDROXY-A-METHYLAMINOACETOPHENONE
3,4-dihydroxy-alpha-methylaminoacetophenone
3’,4’-dihydroxy-2-(methylamino)-acetophenon
3’,4’-dihydroxy-2-(methylamino)acetophenone
1-(3,4-dihydroxyphenyl)-2-(methylamino)-ethanon
1-(3,4-DIHYDROXY-PHENYL)-2-METHYLAMINO-ETHANONE
Ethanone, 1-(3,4-dihydroxyphenyl)-2-(methylamino)- | [EINECS(EC#)]
202-756-9 | [Molecular Formula]
C9H11NO3 | [MDL Number]
MFCD00707523 | [MOL File]
99-45-6.mol | [Molecular Weight]
181.19 |
| Chemical Properties | Back Directory | [Melting point ]
235.5°C (rough estimate) | [Boiling point ]
314.29°C (rough estimate) | [density ]
1.2375 (rough estimate) | [refractive index ]
1.5270 (estimate) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Aqueous Acid (Slightly) | [form ]
Solid | [pka]
7.32±0.20(Predicted) | [color ]
Pale Yellow to Light Yellow | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C9H11NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,10-12H,5H2,1H3 | [InChIKey]
PZMVOUYYNKPMSI-UHFFFAOYSA-N | [SMILES]
C(=O)(C1=CC=C(O)C(O)=C1)CNC |
| Hazard Information | Back Directory | [Chemical Properties]
Needle-shaped crystals. Decomposition temperature 235-236°C. Slightly soluble in water, alcohol, and ether. Its hydrochloride, melting point 243°C, is easily soluble in water and ethanol, but insoluble in ether. | [Originator]
Adrenalone ,Yick-Vic Chemicals and
Pharmaceuticals (HK) Ltd. | [Uses]
Adrenergic (ophthalmic). | [Definition]
ChEBI: Adrenalone is an aromatic ketone. | [Preparation]
Preparation by reaction of excess 33% aqueous methylamine with 3,4-dihydroxy-a-chloroacetophenone. | [Manufacturing Process]
To a suspension of 1 part ω-chloro-3,4-dihydroxyacetophenone (prerared from
chloroacetyl chloride and benzcatechole, see J. Russ. Phys. Chem. Ges., 25,
154) was added dropwise 1 part 60% solution of methylamine. Immediately
was formed a residue of the salt of methylamine and ω-chloro-3,4-
dihydroxyacetophenone. The dissolution of the salt was carried out by heating
of the mixture. Then the salt was converted in crude 3,4-dihydroxy-α-
methylaminoacetophenone. The product was dissolved in dilute hydrochloric
acid. To this solution was added dropwise aqueous ammonium solution to
prepare light yellow crystal of 3,4-dihydroxy-α-methylaminoacetophenone.
The base and the hydrochloride of 3,4-dihydroxy-α-methylaminoacetophenone
decomposed at temperature near 230°C and 240°C respectively. | [Therapeutic Function]
Hemostatic, Sympathomimetic, Vasoconstrictor |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|