| Identification | Back Directory | [Name]
Kushenol C | [CAS]
99119-73-0 | [Synonyms]
Kushenol C
2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]- | [Molecular Formula]
C25H26O7 | [MDL Number]
MFCD30475689 | [MOL File]
99119-73-0.mol | [Molecular Weight]
438.47 |
| Hazard Information | Back Directory | [Uses]
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 μM[1][2]. | [References]
[1] Cho BO, et al. In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophoraflavescens. Molecules. 2020;25(8):1768. Published 2020 Apr 12. DOI:10.3390/molecules25081768
[2] Jung HA, et al. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med. 2010;38(2):415-429. DOI:10.1142/S0192415X10007944 |
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