| Identification | Back Directory | [Name]
Prosaikogenin F | [CAS]
99365-20-5 | [Synonyms]
Prosapogenin F
Prosaikogenin F
VQBQVYADHPXLAM-LLYXJXEPSA-N
3-O-β-D-fucopyranosylsaikogenin F
(13,28-Epoxy-16β,23-dihydroxy-5α-olean-11-en-3β-yl)6-deoxy-β-D-galactopyranoside | [Molecular Formula]
C36H58O8 | [MDL Number]
MFCD34567002 | [MOL File]
99365-20-5.mol | [Molecular Weight]
618.841 |
| Chemical Properties | Back Directory | [Melting point ]
246-250 °C | [Boiling point ]
722.4±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.04±0.70(Predicted) | [color ]
White to off-white | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Prosaikogenin F is a monoglycoside with anticancer and hemolytic properties[1][2]. | [in vivo]
In mice, intraperitoneal administration of Saikosaponin A and its intestinal metabolite, Prosaikogenin F, show corticosterone secretion-inducing activity at a dose of 0.1 mmol/kg, and maximally increase it at a dose of 0.4 mmol/kg[3]. | [References]
[1] Lu Shi, et al. A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San. Curr Med Sci. 2020 Feb;40(1):138-144. DOI:10.1007/s11596-020-2157-5
[2] M Nose, S Amagaya, et al. Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane. Chem Pharm Bull (Tokyo). 1989 Dec;37(12):3306-10. DOI:10.1248/cpb.37.3306
[3] M Nose, et al. Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract. Chem Pharm Bull (Tokyo). 1989 Oct;37(10):2736-40. DOI:10.1248/cpb.37.2736 |
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