| Identification | Back Directory | [Name]
Domperidone maleate | [CAS]
99497-03-7 | [Synonyms]
DOMPERIDONE MALEATE
E-Domperidone Maleate
6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate
2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate
Domperidone maleateQ: What is
Domperidone maleate Q: What is the CAS Number of
Domperidone maleate Q: What is the storage condition of
Domperidone maleate | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C26H28ClN5O6 | [MDL Number]
MFCD07370074 | [MOL File]
99497-03-7.mol | [Molecular Weight]
541.98 |
| Chemical Properties | Back Directory | [Appearance]
White or almost white powder. | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Very slightly soluble in water, sparingly soluble in dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent). | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
Domperidone maleate occurs as a white or almost white powder that exhibits polymorphism. It is very slightly soluble in water or alcohol.
| [Description]
Domperidone maleate is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. | [Uses]
Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. | [Indications]
Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition. | [Side effects]
Because plasma prolactin levels may be increased, galactorrhea or gynecomastia may result. Injectable products (now withdrawn) have been associated with arrhythmias in human patients with heart disease or hypokalemia. Rarely, somnolence or dystonic reac- tions have occurred in people. |
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