| Identification | More | [Name]
Chloromethyl isopropyl carbonate | [CAS]
35180-01-9 | [Synonyms]
CHLOROMETHYL ISOPROPYL CARBONATE
CMIC
I-PROPYL CHLOROMETHYL CARBONATE
Chloromethyl (1-Methylethyl) Carbonate
Chloromethyl-2-propyl carbonate
L-Propylchloromethylcarbonate
Chloromethyl Isopropyl Carbonate (JMC-1)
Chloromethy Isopropyl carbonate | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C5H9ClO3 | [MDL Number]
MFCD07375443 | [Molecular Weight]
152.58 | [MOL File]
35180-01-9.mol |
| Chemical Properties | Back Directory | [Boiling point ]
66 °C(Press: 16 Torr) | [density ]
1.14 | [refractive index ]
1.4110-1.4150 | [Fp ]
50° | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), DMSO, Ethyl Acetate (Slightly) | [form ]
clear liquid | [color ]
Colorless to Almost colorless | [Stability:]
Moisture sensitive | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C5H9ClO3/c1-4(2)9-5(7)8-3-6/h4H,3H2,1-2H3 | [InChIKey]
JHYNXXBAHWPABC-UHFFFAOYSA-N | [SMILES]
C(OC(C)C)(=O)OCCl | [CAS DataBase Reference]
35180-01-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS07,GHS09 | [Signal word ]
Warning | [Hazard statements ]
H315-H317-H411 | [Precautionary statements ]
P280 | [Safety Statements ]
24/25 | [RIDADR ]
2924 | [WGK Germany ]
WGK 3 | [REACH Registrations]
Active | [HazardClass ]
3/8 | [PackingGroup ]
Ⅲ | [HS Code ]
29189900 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Aquatic Chronic 2
Skin Irrit. 2
Skin Sens. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Colourless Liquid | [Uses]
Chloromethyl Isopropyl Carbonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent. | [Synthesis]
At 0-5°C, a photoinitiator is added, and dimethyl carbonate and chlorine are subjected to light reaction. The reaction is stopped, and the product is distilled and separated to obtain dimethyl monochlorocarbonate. At 70-100°C, a catalyst is added, and dimethyl monochlorocarbonate and isopropanol are added to a distillation tower capable of controlling the reflux ratio. Methanol is distilled and separated under normal pressure while reacting. After the reaction is completed, excess isopropanol is distilled off under reduced pressure, and finally chloromethyl isopropyl carbonate is distilled under reduced pressure.
| [References]
[1] Tetrahedron, 2011, vol. 67, # 29, p. 5319 - 5328
[2] Patent: JP2015/164934, 2015, A. Location in patent: Paragraph 0195
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 3, p. 771 - 778
[4] Patent: WO2004/92189, 2004, A1. Location in patent: Page 29
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 23, p. 9133 - 9153 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|