| Identification | Back Directory | [Name]
NEUROPEPTIDE Y (HUMAN, RAT) | [CAS]
99575-89-0 | [Synonyms]
NPY (HUMAN, RAT)
NEUROPEPTIDE Y, HUMAN
NPY FREE ACID (HUMAN, RAT)
NEUROPEPTIDE Y (HUMAN, RAT)
[D-Trp34]-NPY, human-[D-Trp34]
YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY
NEUROPEPTIDE Y FREE ACID (HUMAN, RAT)
Neuropeptide Y (pig),17-L-methionine-36-L-tyrosine-
Neuropeptide Y (free acid) (huMan, rat)
NPY (free acid) (huMan, rat)
TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-NH2: YPSKPDNPGEDAPAEDMARYYSAL-NH2
TYP-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR
TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2
H-TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-OH | [Molecular Formula]
C189H285N55O57S | [MDL Number]
MFCD00081793 |
| Chemical Properties | Back Directory | [storage temp. ]
-15°C | [Sequence]
Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr |
| Hazard Information | Back Directory | [Uses]
Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling[1][2][4]. | [References]
[1] Cajado et al. Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. Toxicol Sci. 2014 Dec;142(2):418-26. DOI:10.1093/toxsci/kfu193
[2] Sung CP, et al. Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes. Circ Res. 1991 Jan;68(1):314-8. DOI:10.1161/01.res.68.1.314
[3] Gordon EA, et al. Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. J Neurochem. 1990 Aug;55(2):506-13. DOI:10.1111/j.1471-4159.1990.tb04164.x
[4] Chaehee Park, et al. Structural basis of neuropeptide Y signaling through Y1 receptor. Nat Commun. 2022 Feb 14;13(1):853. DOI:10.1038/s41467-022-28510-6 |
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