| Identification | Back Directory | [Name]
kazinol B | [CAS]
99624-27-8 | [Synonyms]
kazinol B
Aids096026
Aids-096026
6-[(2S)-7-hydroxy-3,4-dihydro-2H-chromen-2-yl]-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-8-ol
[2,6'-Bi-2H-1-benzopyran]-7,8'-diol, 3,4-dihydro-2',2'-dimethyl-7'-(3-methyl-2-buten-1-yl)-, (2S)- | [Molecular Formula]
C25H28O4 | [MDL Number]
MFCD32644911 | [MOL File]
99624-27-8.mol | [Molecular Weight]
392.49 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [InChI]
InChI=1S/C25H28O4/c1-15(2)5-9-19-20(13-17-11-12-25(3,4)29-24(17)23(19)27)21-10-7-16-6-8-18(26)14-22(16)28-21/h5-6,8,11-14,21,26-27H,7,9-10H2,1-4H3/t21-/m0/s1 | [InChIKey]
QSCBHDIGHKHWKC-NRFANRHFSA-N | [SMILES]
[C@H]1(C2C=C3C(=C(O)C=2C/C=C(/C)\C)OC(C)(C)C=C3)OC2=CC(O)=CC=C2CC1 |
| Hazard Information | Back Directory | [Uses]
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research[1][2]. | [target]
Calcium Channel | Sodium Channel | ATPase | NOS | PI3K | PKC | p38MAPK | PPAR | GLUT | Akt | AMPK | [IC 50]
AMPK | [References]
[1] Hyejin Lee, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6. DOI:10.1016/j.fitote.2016.05.006
[2] Jae-Ha Ryu, et al. Fitoterapia. 2003 Jun;74(4):350-4.Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki. DOI:10.1016/s0367-326x(03)00062-5 |
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