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10030-73-6

中文名称 (9E)-9-十六烯酸
英文名称 PALMITELAIDIC ACID
CAS 10030-73-6
分子式 C16H30O2
分子量 254.41
MOL 文件 10030-73-6.mol
10030-73-6 结构式 10030-73-6 结构式

基本信息

中文别名
棕榈酸酯?
反式-棕榈油酸
十六碳烯酸(反-9)
反式-9-十六碳烯酸
(9E)-9-十六烯酸
英文别名
PALMITELAIDIC ACID
C16:1 (TRANS-9) ACID
(e)-9-hexadecenoicaci
(E)-9-Hexadecenoicacid
PALMITELAIDIC ACID 99%
trans-palmitoleic acid
(9E)-9-Hexadecenoicacid
(9E)-Hexadec-9-enoic acid
TRANS-9-HEXADECENOIC ACID
9-trans-Hexadecenoic acid

物理化学性质

熔点33-34℃
沸点374.4°C (estimate)
密度0.8855 (rough estimate)
折射率1.4501 (589.3 nm 40℃)
储存条件Amber Vial, Refrigerator
溶解度可溶于DMSO(少量)、甲醇(少量)
酸度系数(pKa)4.78±0.10(Predicted)
形态液体
颜色白色至灰白色
LogP6.635 (est)

常见问题列表

生物活性
Palmitelaidic Acid (9-trans-Hexadecenoic acid) 是棕榈油酸 palmitoleic acid 的反式异构体。 棕榈油酸是血清和组织中最丰富的脂肪酸之一。
靶点

AMPK

PPARα

Glucokinase

体外研究

The monounsaturated fatty acid palmitoleate (palmitoleic acid) is one of the most abundant fatty acids in serum and tissues, particularly adipose tissue and liver. Its endogenous production by stearoyl-CoA desaturase 1 gives rise to its cis isoform, cis-palmitoleate. Palmitoleic acid has been correlated with multiple cardiometabolic risk factors, including high blood pressure, total cholesterol, TGs, apoA-I, apoB, and endothelial dysfunction.

体内研究

Palmitoleic acid promotes a faster uptake of glucose in the body, associated with higher insulin concentration. Palmitoleic acid increases the phosphorylation of AMPK, up-regulates glucokinase and down-regulates SREBP-1. Regarding AMPK downstream, palmitoleic acid increases the production of FGF-21 and stimulates the expression of PPARα. Palmitoleic acid reduces body weight increase, ameliorates the development of hyperglycemia and hypertriglyceridemia, and improves insulin sensitivity. Furthermore, palmitoleic acid down-regulates mRNA expressions of proinflammatory adipocytokine genes (TNFα and resistin) in white adipose tissue and lipogenic genes (SREBP-1, FAS, and SCD-1) in liver.

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