10179-57-4
中文名称
MLS-573151
英文名称
MLS-573151
CAS
10179-57-4
分子式
C21H19N3O2S
分子量
377.46
MOL 文件
10179-57-4.mol
更新日期
2024/05/11 14:52:49
10179-57-4 结构式
基本信息
中文别名
化合物MLS-573151 英文别名
MLS-573151Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-
物理化学性质
储存条件RT
溶解度溶于DMSO(高达20mg/ml)。
形态固体
颜色黄色
稳定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
常见问题列表
生物活性
MLS-573151 (MLS000573151) 是一种选择性 GTPase Cdc42 的抑制剂,EC50 为 2 μM。MLS-573151 对其他 GTPases 家族成员无效,例如 Rab2,Rab7,H-Ras,Rac1,Rac 2 和 RhoA 野生型。MLS-573151 通过阻止 GTP 与 Cdc42 的结合来发挥作用。体外研究
The fluorescence intensities of phagocytosed beads or bacteria in hemocytes, taken as a measure of phagocytosis efficiency, were markedly reduced in granulocytes treated with MLS-573151 (50 μM; for 15 min) compared to that in the control group. MLS-573151 could effectively inhibit the phagocytic ability of granulocytes.