105184-37-0
中文名称
L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐
英文名称
ARG-LYS-GLU-VAL-TYR ACETATE SALT
CAS
105184-37-0
分子式
C33H55N9O11
分子量
753.84
MOL 文件
105184-37-0.mol
更新日期
2024/04/30 16:16:02
105184-37-0 结构式
基本信息
中文别名
脾脏五肽醋酸脾脏五肽
L-精氨酰-L-赖氨酰-L-ALPHA-谷氨酰-L-缬氨酰-L-酪氨酸二醋酸盐
英文别名
SP-5 ACETATE SALTSplenopentin diacetate
SPLENOPENTIN ACETATE SALT
ARG-LYS-GLU-VAL-TYR ACETATE
SP-5, Splenin Fragment 32-36
ARG-LYS-GLU-VAL-TYR ACETATE SALT
SPLENIN FRAGMENT 32-36 ACETATE SALT
ARG-LYS-GLU-VAL-TYR ACETATE SALT USP/EP/BP
SP-5, Splenin Fragment 32-36, Splenopentin
L-Arginyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-tyrosine diacetate
所属类别
生物化工：酪氨酸类衍生物常见问题列表
生物活性
Splenopentin diacetate 是一种合成的免疫调节性五肽，对应于脾脏激素脾脏蛋白的残基 32-36。Splenopentin diacetate 可影响早期的 T 细胞和 B 细胞分化，从而增加 γ 射线照射后小鼠体内抗体形成细胞的数量。体外研究
Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.
体内研究
Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice.
| Animal Model: | Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days |
| Dosage: | 1 mg/kg |
| Administration: | I.p. three times a week for 7-90 days |
| Result: |
Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops. |