105812-81-5

基本信息
反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶
(-)反式-4R(4-氟苯基)-3R-羟甲基-1-甲基哌啶
(-)反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶
(3S,4R)-1-甲基-3-羟甲基-4-(4-氟苯基)哌啶
(-)反式-4R(4-氟苯基)-3R-羟甲基-1-甲基哌啶
(3S,4R)-4-(4-氟苯基)-1-甲基-3-哌啶甲醇,98%
(3S,4R)-4-(4'-FLUOROPHENYL)-3-HYDROXYMETHYL-1-METHYLPIPERIDINE
(3S,4R)-4-(4-FLUOROPHENYL)-3-HYDROXYMETHYL-1-METHYLPIPERIDINE
(4R,3S)-4-(4-FLUOROPHENYL)-3-HYDROXY METHYL-N-METHYL PIPERIDINE
(-)-TRANS-4-(4-FLUOROPHENYL)-3-HYDROXYMETHYL-1-METHYLPIPERIDINE
TRANS-(-)-4-FLUOROPHENYL-1-METHYL-3-PIPERIDINE METHANOL
(-)-TRANS-4R-(4-FLUOROPHENYL)-3S-HYDROXYMETHYL-1-METHYLPIPERIDINE
Trans-(-)-4-(4-Fluorophenyl)-1-Methyl-3-Piperidine Methanol
PAROXOL
4, (-)trans-4R-(4-fluorophenyl)-3S-hydroxymethyl-1-methylpiperidine
3-Piperidinemethanol,4-(4-fluorophenyl)-1-methyl-,(3S,4R)-
(4S,3S)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol
(3S,4R)-4-(4-Fluorophenyl)-3-h
(2S)-1-(4-FLUOROPHENYL)-4-METHYLPIPERAZIN-2-YL]METHANOL
(-)-Trans-4R-(4-Fluorophenyl)-3S-hydroxymethyl-N-methylpiperidine
(3S,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol, 98%
物理化学性质
安全数据
制备方法

335158-58-2

105812-81-5
以化合物(CAS:335158-58-2)为原料合成(3S,4R)-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的一般步骤如下:在配备有搅拌器、冷凝器和温度计的500 mL圆底烧瓶中,加入31.4 g反式-N-甲基-4'-氟苯基-3-甲氧基哌啶和100 mL四氢呋喃。随后,向反应体系中缓慢加入3.31 g氢化铝锂,同时控制反应温度维持在10℃。加料完毕后,继续搅拌反应混合物直至反应完成。反应完成后,缓慢加入50 mL蒸馏水和30 mL 10%氢氧化钠水溶液,继续搅拌30分钟。接着,向反应混合物中加入200 mL乙酸乙酯,再搅拌30分钟。分离有机相和水相,蒸馏除去溶剂及低沸点有机物质。剩余物通过甲苯和正庚烷的混合溶液进行重结晶,得到目标产物反式-N-甲基-4'-氟苯基-3-羟甲基哌啶(产率:78.4%,纯度:99.3%)。产物的Rf值为0.3(展开剂:二氯甲烷/甲醇,4:1)。1H NMR(CDCl3,200 MHz)数据如下:δ 7.18(t,2H,J = 8.7 Hz);6.98(t,2H,J = 8.7 Hz);3.39(dd,1H,J = 10.6 Hz,J = 2.8 Hz);3.25-3.14(m,2H);2.93(d,1H,J = 10.8 Hz);2.70(s,1H);2.31(s,3H);2.27-2.21(m,1H);2.09-1.75(m,5H)。
参考文献:
[1] Patent: WO2004/5254, 2004, A1. Location in patent: Page 9
[2] Patent: WO2005/63707, 2005, A1. Location in patent: Page 26
[3] Patent: WO2005/63707, 2005, A1. Location in patent: Page 27
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2025/05/22 | XW10581281502 | (3S,4R)-4-(4-氟苯基)-1-甲基-3-哌啶甲醇 | 105812-81-5 | 25G | 246元 |
2025/05/22 | XW10581281501 | (3S,4R)-4-(4-氟苯基)-1-甲基-3-哌啶甲醇 | 105812-81-5 | 5G | 50元 |
2025/05/22 | F0878 | (3S,4R)-4-(4-氟苯基)-1-甲基-3-哌啶甲醇 (3S,4R)-4-(4-Fluorophenyl)-1-methyl-3-piperidinemethanol | 105812-81-5 | 5g | 480元 |