1149362-88-8
中文名称
(2R,6S)-4-[[[3,5-二(三氟甲基)苯基]甲基][5-(1-甲基-1H-吡唑-4-基)-2-嘧啶基]氨基]-2,6-二乙基-1-哌啶羧酸 反式-4-羧基环己基酯
英文名称
CETPinhibitor
CAS
1149362-88-8
分子式
C34H40F6N6O4
分子量
710.71
MOL 文件
1149362-88-8.mol
1149362-88-8 结构式
基本信息
中文别名
(2R,6S)-4-[[[3,5-二(三氟甲基)苯基]甲基][5-(1-甲基-1H-吡唑-4-基)-2-嘧啶基]氨基]-2,6-二乙基-1-哌啶羧酸 反式-4-羧基环己基酯 英文别名
CETPinhibitor(2R,6S)-rel-4-[[[3,5-Bis(trifluoromethyl)phenyl]methyl][5-(1-methyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino]-2,6-diethyl-1-piperidinecarboxylic acid trans-4-carboxycyclohexyl ester
1-Piperidinecarboxylic acid, 4-[[[3,5-bis(trifluoromethyl)phenyl]methyl][5-(1-methyl-1H-pyrazol-4-yl)-2-pyrimidinyl]amino]-2,6-diethyl-, trans-4-carboxycyclohexyl ester, (2R,6S)-rel-
物理化学性质
沸点750.115±70.00 °C(Press: 760.00 Torr)(predicted)
密度1.404±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
酸度系数(pKa)4.594±0.10(predicted)
应用领域
用途一
TAP311 is a novel, piperidine-based inhibitor of cholesteryl ester transfer protein (CETP). It has a core structure distinct from other reported CETP inhibitors. CETP inhibitors have therapeutic potential against coronary heart disease as they mediate chemical exchange involving cholesterol. TAP311 has a limited lipophilicity, improving pharmacological profile. It is under clinical trials.