1196800-39-1
中文名称
1196800-39-1
英文名称
Omadacycline (hydrochloride)
CAS
1196800-39-1
分子式
C29H41ClN4O7
分子量
593.12
MOL 文件
1196800-39-1.mol
更新日期
2024/11/15 18:20:32
1196800-39-1 结构式
基本信息
英文别名
omadacycline HClPTK0796 hydrochloride
PTK-0796 hydrochloride
PTK 0796 hydrochloride
Amadacycline hydrochloride
Omadacycline (hydrochloride)
PTK 0796 HYDROCHLORIDE
PTK-0796 HYDROCHLORIDE
PTK0796 HYDROCHLORIDE
AMADACYCLINE HYDROCHLORIDE
(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-9-[(2,2-dimethylpropylamino)methyl]-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
应用领域
用途一
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.常见问题列表
概述
Omadacycline (PTK 0796) hydrochloride，首创的具有口服活性的氨基甲基环素抗菌剂，是一种四环素类抗生素。Omadacycline hydrochloride 通过与 30S 核糖体亚基结合来抑制细菌蛋白质的合成。Omadacycline hydrochloride 对多种细菌表现出活性，包括好氧和厌氧革兰氏阳性细菌和革兰氏阴性细菌，非典型病原体。Omadacycline hydrochloride 可用于研究急性细菌性皮肤和皮肤结构感染，感染性肺炎和尿路感染。